It’s just a matter of shot placement right? .22 would give you the least recoil and easiest follow up shots wouldn’t it? Penetration is decent enough too, and there’s no deafening bang to concuss you. Conversely over penetration is not much of an issue with it either. So why aren’t we all using it?
Have I thoroughly baited you? Hope so, while this was mostly tongue in cheek these very reasons were the impetus behind the American 180. An interesting sub machinegun in .22lr.

But to the real discussion, there is often a discussion over shot placement and stopping power. If you somehow are unfamiliar with that (how did you even end up here?!) it come down to the placement camp says that the placement of the bullet is most important in stopping someone and the power camp says that the amount of energy imparted into the target is most import.
Both have there merits, but there has to be an upper and lower bound? Like the article opened with; why not just use .22, or on the other end say .50AE?
So what is the minimum? What is the max? Make your case below.
(I would say keep it a civil debate but this is the internet, let it fly!)